更新日期:2018年8月31日
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姓 名
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石晓钟
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性 别
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男
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出生年月
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1975年12月
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籍贯
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江西波阳县
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民 族
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汉族
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政治面貌
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群众
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最后学历
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博士研究生
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最后学位
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理学博士
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技术职称
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教授
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导师类别
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博、硕导
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行政职务
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Email
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xiaozhongshi@scut.edu.cn
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工作单位
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生物科学与工程学院
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邮政编码
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510006
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通讯地址
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广州市番禺区大学城
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单位电话
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020-39380620
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工作经历
2002年加入美国德州大学西南医学中心,从事博士后研究;2007年加入明尼苏达州立大学医学院,任职助理教授;2016年加入华南理工大学生物科学与工程学院,任职教授。
教育经历
1997毕业于 厦门大学,获理学学士;2002毕业于中国科学院上海生命科学研究院,获理学博士学位。
社会、学会及学术兼职
广东省生物医学工程学会会员
研究领域
长期从事基因表达的转录调控领域研究,主要研究方向为骨骼肌分化过程中的转录调控。实验研究技术包括:生物化学、分子生物学、细胞生物学、动物体内基因敲除和转基因技术,及胚胎干细胞体外培养等。
科研项目
1. 华南理工大学,杰出人才引进计划,2017-2022,课题负责人;
2,自然科学基金,骨骼肌分化过程中的转录调控,2018-2021,课题负责人。
发表论文
1. Feedback Mechanisms Regulate Ets Variant 2 (Etv2) Gene Expression and Hematoendothelial Lineages. Koyano-Nakagawa N, Shi X, Rasmussen TL, Das S, Walter CA, Garry DJ. J Biol Chem. 2015 Nov 20;290(47):28107-19.
2. The Etv2-miR-130a Network Regulates Mesodermal Specification.
Singh BN, Kawakami Y, Akiyama R, Rasmussen TL, Garry MG, Gong W, Das S, Shi X, Koyano-Nakagawa N, Garry DJ. Cell Rep. 2015 Nov 3;13(5):915-23.
3. Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex. Gong W, Gohla RM, Bowlin KM, Koyano-Nakagawa N, Garry DJ, Shi X. J Biol Chem. 2015 Jun 12;290(24):15350-61.
4. The transcription factor Mesp1 interacts with cAMP-responsive element binding protein 1 (Creb1) and coactivates Ets variant 2 (Etv2) gene expression. Shi X, Zirbes KM, Rasmussen TL, Ferdous A, Garry MG, Koyano-Nakagawa N, Garry DJ.
J Biol Chem. 2015 Apr 10;290(15):9614-25.
5. Sox7 is regulated by ETV2 during cardiovascular development. Behrens AN, Zierold C, Shi X, Ren Y, Koyano-Nakagawa N, Garry DJ, Martin CM.
Stem Cells Dev. 2014 Sep 1;23(17):2004-13.
6. Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages. Shi X, Richard J, Zirbes KM, Gong W, Lin G, Kyba M, Thomson JA, Koyano-Nakagawa N, Garry DJ. Dev Biol. 2014 May 15;389(2):208-18.
7. Kbtbd5 is regulated by MyoD and restricted to the myogenic lineage. Bowlin KM, Embree LJ, Garry MG, Garry DJ, Shi X. Differentiation. 2013 Nov-Dec;86(4-5):184-91.
8. Etv2 rescues Flk1 mutant embryoid bodies. Rasmussen TL, Martin CM, Walter CA, Shi X, Perlingeiro R, Koyano-Nakagawa N, Garry DJ. Genesis. 2013 Jul;51(7):471-80.
9. Mesp1 patterns mesoderm into cardiac, hematopoietic, or skeletal myogenic progenitors in a context-dependent manner. Chan SS, Shi X, Toyama A, Arpke RW, Dandapat A, Iacovino M, Kang J, Le G, Hagen HR, Garry DJ, Kyba M. Cell Stem Cell. 2013 May 2;12(5):587-601.
10. Foxk1 promotes cell proliferation and represses myogenic differentiation by regulating Foxo4 and Mef2. Shi X, Wallis AM, Gerard RD, Voelker KA, Grange RW, DePinho RA, Garry MG, Garry DJ. J Cell Sci. 2012 Nov 15;125(Pt 22):5329-37.
11. Foxk1 recruits the Sds3 complex and represses gene expression in myogenic progenitors. Shi X, Seldin DC, Garry DJ. Biochem J. 2012 Sep 15;446(3):349-57.
12. Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression. Koyano-Nakagawa N, Kweon J, Iacovino M, Shi X, Rasmussen TL, Borges L, Zirbes KM, Li T, Perlingeiro RC, Kyba M, Garry DJ. Stem Cells. 2012 Aug;30(8):1611-23.
13. Sin3 interacts with Foxk1 and regulates myogenic progenitors. Shi X, Garry DJ. Mol Cell Biochem. 2012 Jul;366(1-2):251-8.
14. VEGF/Flk1 signaling cascade transactivates Etv2 gene expression. Rasmussen TL, Shi X, Wallis A, Kweon J, Zirbes KM, Koyano-Nakagawa N, Garry DJ. PLoS One. 2012;7(11):e50103.
15. ER71 directs mesodermal fate decisions during embryogenesis. Rasmussen TL, Kweon J, Diekmann MA, Belema-Bedada F, Song Q, Bowlin K, Shi X, Ferdous A, Li T, Kyba M, Metzger JM, Koyano-Nakagawa N, Garry DJ. Development. 2011 Nov;138(21):4801-12.
16. Nkx2-5 represses Gata1 gene expression and modulates the cellular fate of cardiac progenitors during embryogenesis. Caprioli A, Koyano-Nakagawa N, Iacovino M, Shi X, Ferdous A, Harvey RP, Olson EN, Kyba M, Garry DJ. Circulation. 2011 Apr 19;123(15):1633-41.
教学活动
本科生理论课《干细胞前沿技术》、 《干细胞生物学》、《癌症生物学》和本科生实验课《细胞生物学实验》; 研究生课程《分子生物学实验方法》。