华南理工大学教师信息

关闭

1. 工作经历
2. 教育经历
3. 获奖荣誉
4. 社会兼职
5. 研究领域
6. 科研项目
7. 发表论文
8. 专著教材
9. 科研创新
10. 教学活动
11. 指导学生
12. 我的团队

更新日期：2023年6月19日

姓名	傅宏鑫	性别	男
出生年月	1986年1月	籍贯	山西寿阳县
民族	汉族	政治面貌	中国共产党党员
最后学历	博士研究生	最后学位	工学博士
技术职称	副教授	导师类别	硕导
行政职务		Email	hongxinfu@scut.edu.cn
工作单位	华南理工大学生物科学与工程学院	邮政编码	510006
通讯地址	华南理工大学大学城校区B6-516
单位电话

工作经历

2016.12-2019.12       华南理工大学      师资博士后（助理研究员）
2018.09-2020.08       华南理工大学      博士后副研究员
2020.09-至今             华南理工大学      副教授

教育经历

2009-2016 大连理工大学生物化工硕博连读
2013-2015 俄亥俄州立大学联合培养博士

获奖、荣誉称号

2018-2019学年第一学期本科课堂教学质量优秀教师奖
2018-2019学年本科生班主任工作考核优秀奖

社会、学会及学术兼职

客座编辑
Frontiers in Bioengineering and Biotechnology

审稿人
JCR一区期刊：Critical Reviews in Biotechnology, Bioresource Technology, Metabolic Engineering, Journal of Cleaner Production, Biotechnology for Biofuels and Bioproducts, Journal of Environmental Management, ACS Sustainable Chemistry & Engineering, Renewable Energy, Green Energy & Environment, Separation and Purification Technology, Industrial Crops and Products, Environmental Research, Frontiers in Microbiology, Frontiers in Bioengineering and Biotechnology, Cell Reports Physical Science
JCR二区期刊：Industrial & Engineering Chemistry Research, Environmental Microbiology, Biotechnology and Bioengineering, Process Biochemistry, Environmental Science and Pollution Research, Chinese Journal of Chemical Engineering, Food and Bioproducts Processing
JCR三区期刊：Biotechnology Progress，Frontiers in Energy Research

研究领域

(1) 代谢工程构建高效生产菌株;
(2) 利用廉价原料发酵生产生物基化学品和生物燃料;
(3) 发酵过程控制及优化;
(4) 生物基化学品和生物燃料的下游分离工艺。

科研项目

主持
(1) 国家自然科学基金（21808069, 25万元）
(2) 广东省级科技计划项目子课题（2020B1111030005，30万元）
(3) 广东省自然科学基金项目（2023A1515030100，30万元）
(4) 广东省自然科学基金项目（2018A030310368，10万元）
(5) 广州市科技项目（202102020281, 5万元）
(6) 博士后科学基金特别资助（2018T110871, 15万元）
(7) 博士后科学基金面上资助（2017M612667, 5万元）
(8) 中央高校基本科研业务费（2017BQ084, 5万元）

参与
(1) 国家自然科学基金面上项目 (22178133, 60万元)
(2) 国家自然科学基金面上项目 (21878103, 65万元)
(3) 国家自然科学基金面上项目 (21676098, 75万元)
(4) 广东省科技计划项目（2019A050510008, 50万元）
(5) "863"子课题 (2012AA021202-3, 110万元)
(6)“年产千吨级生物基 1,3-丙二醇工业化示范”项目，2010-2013年。

发表论文

[1] Ziyao Liu, Xiaolong Guo, Kaiqun Dai, Jun Feng, Tiantian Zhou, Hongxin Fu, Jufang Wang*. Biosynthesis of gamma-aminobutyric acid by engineered Clostridium tyrobutyricum co-overexpressing glutamate decarboxylase and class I heat shock protein. Fermentation-Basel, 2023, 9(5), 445. （二区，IF=5.123）
[2] Xiaolong Guo, Huihui Zhang, Feng Jun, Lu Yang, Kui Luo, Hongxin Fu*, Jufang Wang*. De novo biosynthesis of butyl butyrate in engineered Clostridium tyrobutyricum. Metabolic Engineering, 2023, 77: 64–75. （一区top，IF=8.892）
[3] Hongxin Fu*, Lu Yang, Huihui Zhang, Jufang Wang*. Deciphering of the mannitol metabolism pathway in Clostridium tyrobutyricum ATCC 25755 by comparative transcriptome analysis. Applied Biochemistry and Biotechnology, 2023, 195:1072-1084. （三区，IF=3.094）
[4] Kui Luo, Xiaolong Guo, Huihui Zhang, Hongxin Fu, Jufang Wang*. The physiological functions of AbrB on sporulation, biofilm formation and carbon source utilization in Clostridium tyrobutyricum. Bioengineering-Basel，2022，9(10):575. （二区，IF=5.046）
[5] Hongxin Fu*, Zhi Yue, Jun Feng, Teng Bao, Shang-Tian Yang, Youhua Cai, Jufang Wang*. Consolidated bioprocessing for butyric acid production from raw cassava starch by a newly isolated Clostridium butyricum SCUT620. Industrial Crops and Products, 2022, 187:115446. （一区top, IF=6.449）
[6] Kaiqun Dai, Hongxin Fu, Xiaolong Guo, Chunyun Qu, Yang Lan, Jufang Wang*. Exploiting the type I-B CRISPR genome editing system in Thermoanaerobacterium aotearoense SCUT27 and engineering the strain for enhanced ethanol production. Applied and Environmental Microbiology, 2022, 88(15):e0075122. （二区top，IF=5.005）
[7] Jun Feng, Xiaolong Guo, Feifei Cai, Hongxin Fu* and Jufang Wang*. Model-based driving mechanism analysis for butyric acid production in Clostridium tyrobutyricum. Biotechnology for Biofuels and Bioproducts, 2022, 15:71. （一区top，IF=7.670）
[8] Hongxin Fu, Huihui Zhang, Xiaolong Guo, Lu Yang, Jufang Wang*. Elimination of carbon catabolite repression in Clostridium tyrobutyricum for enhanced butyric acid production from lignocellulosic hydrolysates. Bioresource Technology, 2022, 357:127320. （一区top，IF=11.889）
[9] Hongxin Fu*, Shang-Tian Yang*. Editorial: Development and application of Clostridia as microbial cell-factories for biofuels and biochemicals production. Frontiers in Bioengineering and Biotechnology, 2022, 9:831135. （一区top，IF=60.64）
[10] Yang Lan, Jun Feng, Xiaolong Guo, Hongxin Fu*, Jufang Wang*. Isolation and characterization of a newly identified Clostridium butyricum strain SCUT343-4 for 1,3-propanediol production. Bioprocess and Biosystems Engineering, 2021, 44:2375-2385. （二区，IF=3.434）
[11] Hongxin Fu, Jialei Hu, Xiaolong Guo, Feng Jun, Shang-Tian Yang, Jufang Wang*. Butanol production from Saccharina japonica hydrolysate by engineered Clostridium tyrobutyricum: The effects of pretreatment method and heat shock protein overexpression. Bioresource Technology, 2021, 335:125290. （一区top，IF=11.889）
[12] Hongxin Fu, Sheng Luo, Kaiqun Dai, Chunyun Qu, Jufang Wang*. Engineering Thermoanaerobacterium aotearoense SCUT27/Δldh with pyruvate formate lyase-activating protein (PflA) knockout for enhanced ethanol tolerance and production. Process Biochemistry, 2021, 106:184-190. （二区，IF=4.855）
[13] Chunyun Qu, Kaiqun Dai, Hongxin Fu, Jufang Wang*. Enhanced ethanol production from lignocellulosic hydrolysates by Thermoanaerobacterium aotearoense SCUT27/Delta argR(1864) with improved lignocellulose-derived inhibitors tolerance. Renewable Energy, 2021, 173:652-661. （一区top，IF=8.634）
[14] Chunyun Qu, Yang Zhang, Kaiqun Dai, Hongxin Fu, Jufang Wang*. Metabolic engineering of Thermoanaerobacterium aotearoense SCUT27 for glucose and cellobiose co-utilization by identification and overexpression of the endogenous cellobiose operon. Biochemical Engineering Journal, 2021, 1167:107922. （二区，IF=4.446）
[15] Hongxin Fu, Meng Lin, I-Ching Tang, Jufang Wang*, Shang-Tian Yang*. Effects of benzyl viologen on increasing NADH availability, acetate assimilation, and butyric acid production by Clostridium tyrobutyricum. Biotechnology and Bioengineering, 2021, 118:770-783. （二区，IF=4.395，封面文章）
[16] Hongxin Fu*, Jialei Hu, Xiaolong Guo, Jun Feng, Yanan Zhang, Jufang Wang*. High-selectivity butyric acid production from Saccharina japonica hydrolysate by Clostridium tyrobutyricum. Industrial & Engineering Chemistry Research, 2020, 59: 17147-17155. （二区，IF=4.326）
[17] Teng Bao, Feng, Jun Feng, Wenyan Jiang, Hongxin Fu, Jufang Wang, Shang-Tian Yang*. Recent advances in n-butanol and butyrate production using engineered Clostridium tyrobutyricum. World Journal of Microbiology and Biotechnology, 2020, 36:138. （二区top，IF=4.253）
[18] Chunyun Qu, Lili Chen, Hongxin Fu, Jufang Wang*. Engineering Thermoanaerobacterium aotearoense SCUT27 with argR knockout for enhanced ethanol production from lignocellulosic hydrolysates. Bioresource Technology, 2020, 310:123435. （一区top，IF=11.889）
[19] Chunyun Qu, Lili Chen, Yang Li, Hongxin Fu, Jufang Wang*. The redox-sensing transcriptional repressor Rex is important for regulating the products distribution in Thermoanaerobacterium aotearoense SCUT27. Applied Microbiology and Biotechnology, 2020, 104:5605-5617. （二区top，IF=5.560）
[20] Xiaolong Guo#, Hongxin Fu#, Feng Jun, Jialei Hu, Jufang Wang*. Direct conversion of untreated cane molasses into butyric acid by engineered Clostridium tyrobutyricum. Bioresource Technology, 2020, 301:122764. （一区top，IF=11.889）
[21] Zhengping Liao, Xitong Yang, Hongxin Fu*, Jufang Wang*. The significance of aspartate on NAD(H) biosynthesis and ABE fermentation in Clostridium acetobutylicum ATCC 824. AMB Express, 2019, 9:142. （二区top，IF=4.126）
[22] Yang Li, Jialei Hu, Chunyun Qu, Lili Chen, Xiaolong Guo, Hongxin Fu, Jufang Wang*. Engineered Thermoanaerobacterium aotearoense with nfnAB knockout for improved hydrogen production from lignocellulose hydrolysates. Biotechnology for Biofuels, 2019, 12:214. （一区top，IF=7.670）
[23] Hongxin Fu, Xitong Yang, Chunyun Qu, Yang Li, Jufang Wang*. Enhanced ethanol production from lignocellulosic hydrolysates by inhibiting the hydrogen synthesis in Thermoanaerobacterium aotearoense SCUT27(Δldh). Journal of Chemical Technology and Biotechnology, 2019, 94: 3305-3314. （二区top，IF=3.709）
[24] Zhengping Liao, Xiaolong Guo, Jialei Hu, Yukai Suo, Hongxin Fu*, Jufang Wang*. The significance of proline on lignocellulose-derived inhibitors tolerance in Clostridium acetobutylicum ATCC 824. Bioresource Technology, 2019, 272:561-569. （一区top，IF=11.889）
[25] Yukai Suo, Zhengping Liao, Chunyun Qu, Hongxin Fu*, Jufang Wang*. Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production from undetoxified corncob acid hydrolysate. Bioresource Technology, 2019, 271:266-273. （一区top，IF=11.889）
[26] Ling Jiang, Hongxin Fu, Hopen K. Yang, Wei Xu, Jufang Wang*, Shang-Tian Yang*. Butyric acid: Applications and recent advances in its bioproduction. Biotechnology Advances, 2019, 36: 2101-2117. （一区top，IF=17.681）
[27] Zhengping Liao, Yukai Suo, Chuang Xue, Hongxin Fu*, Jufang Wang*. Improving the fermentation performance of Clostridium acetobutylicum ATCC 824 by strengthening the VB1 biosynthesis pathway. Applied Microbiology and Biotechnology, 2018, 102(18): 8107-8119. （二区top，IF=5.560）
[28] Ping Luo, Yanan Zhang, Yukai Suo, Zhengping Liao, Yi Ma, Hongxin Fu*, Jufang Wang*. The global regulator IrrE from Deinococcus radiodurans enhances the furfural tolerance of Saccharomyces cerevisiae. Biochemical Engineering Journal, 2018, 136:69-77.（二区，IF=4.446）
[29] Ling Yan, Yaqin Sun, Xudong Wang, Hongxin Fu, Ying Mu, Zhilong Xiu*. Partition behavior of monocarboxylic acids in salting-out extraction systems of monohydric alcohols and dipotassium phosphate. Separation and Purification Technology, 2018, 199:351-358. （一区top，IF=9.136）
[30] Yukai Suo, Mengmeng Ren, Xitong Yang, Zhengping Liao, Hongxin Fu*, Jufang Wang*. Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production with high butyrate/acetate ratio. Applied Microbiology and Biotechnology, 2018, 102(10): 4511-4522. （二区top，IF=5.560）
[31] Yukai Suo#, Hongxin Fu#, Mengmeng Ren, Zhengping Liao, Yi Ma, Jufang Wang*. Enhanced butyric acid production in Clostridium tyrobutyricum by overexpression of rate-limiting enzymes in the Embden-Meyerhof-Parnas pathway. Journal of Biotechnology, 2018, 272-273:14-21. （二区，IF=4.446）
[32] Yukai Suo#, Hongxin Fu#, Mengmeng Ren, Xitong Yang, Zhengping Liao, Jufang Wang*. Butyric acid production from lignocellulosic biomass hydrolysates by engineered Clostridium tyrobutyricum overexpressing Class I heat shock protein GroESL. Bioresource Technology, 2018, 250:691-698. （一区top，IF=11.889）
[33] Daiana Wischral*, Hongxin Fu, Fernando L. Pellegrini Pessoa, Nei Pereira Jr, Shang-Tian Yang. Effective and simple recovery of 1,3-propanediol from a fermented medium by liquid–liquid extraction system with ethanol and K3PO4. Chinese Journal of Chemical Engineering, 2018, 26(1):104-108. （二区，IF=3.898）
[34] Hongxin Fu#, Xudong Wang#, Yaqin Sun, Ling Yan, Juntao Shen, Jufang Wang, Shang-Tian Yang, Zhilong Xiu*. Effects of salting-out and salting-out extraction on the separation of butyric acid. Separation and Purification Technology, 2017, 180:44-50. （一区top，IF=9.136）
[35] Hongxin Fu, Shang-Tian Yang*, Minqi Wang, Jufang Wang. Butyric acid production from lignocellulosic biomass hydrolysates by engineered Clostridium tyrobutyricum overexpressing xylose catabolism genes for glucose and xylose co-utilization. Bioresource Technology, 2017, 234:389-396. （一区top，IF=11.889）
[36] Hongxin Fu, Le Yu, Meng Lin, Jufang Wang, Zhilong Xiu, Shang-Tian Yang*. Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production from glucose and xylose. Metabolic Engineering, 2017, 40:50-58. （一区top，IF=8.892）
[37] Peilian Wei#, Meng Lin#, Zhongqiang Wang#, Hongxin Fu, Hopen Yang, Wenyan Jiang, Shang-Tian Yang*. Metabolic engineering of Propionibacterium freudenreichii, subsp. shermanii, for xylose fermentation. Bioresource Technology, 2016, 219:91-97. （一区top，IF=11.889）
[38] Juntao Shen, Jinjie Zhou, Hongxin Fu, Ying Mu, Yaqin Sun, Yongping Xu, Zhilong Xiu*. A Klebsiella pneumoniae bacteriophage and its effect on 1,3-propanediol fermentation. Process Biochemistry, 2016, 51(10): 1323-1330. （二区，IF=4.855）
[39] Hongxin Fu, Jianying Dai, Yaqin Sun, Daijia Zhang, Zhilong Xiu*. Partition behavior of hydrophilic diols in an ethanol/ammonium sulfate salting-out extraction system. Engineering in Life Sciences, 2015, 15(8): 797-803. （三区，IF=3.405）
[40] Hongxin Fu, Shang-Tian Yang, Zhilong Xiu*. Phase separation in a salting-out extraction system of ethanol–ammonium sulfate. Separation and Purification Technology, 2015, 148: 32-37. （一区top，IF=9.136）
[41] Hongxin Fu, Yaqin Sun, Hu Teng, Daijia Zhang, Zhilong Xiu*. Salting-out extraction of carboxylic acids. Separation and Purification Technology, 2015, 139: 36-42. （一区top，IF=9.136）
[42] Yaqin Sun, Ling Yan, Hongxin Fu, Zhilong Xiu*. Salting-out extraction and crystallization of succinic acid from fermentation broths. Process Biochemistry, 2014, 49(3):506-511.（二区，IF=4.855）
[43] Yaqin Sun, Ling Yan, Hongxin Fu, Zhilong Xiu*. Selection and optimization of a salting-out extraction system for recovery of biobutanol from fermentation broth. Engineering in Life Sciences, 2013, 13(5): 464-471. （三区，IF=3.405）
[44] Hongxin Fu, Yaqin Sun, Zhilong Xiu*. Continuous countercurrent salting-out extraction of 1,3-propanediol from fermentation broth in a packed column. Process Biochemistry, 2013, 48(9):1381-1386.（二区，IF=4.855）

出版专著和教材

[1] Yanqin Sun, Chengwei Ma, Hongxin Fu, Ying Mu, Zhilong Xiu*. Bioprocessing of renewable resources to commodity products (Chapter 11: 1,3-propanediol). John Wiley & Sons, Inc., New York, NY, 2014.

科研创新

[1]  傅宏鑫，王菊芳, 任梦梦。一种提高嗜热厌氧杆菌发酵性能的方法。中国发明专利：2019107517030。（已授权）
[2]  王菊芳，冯骏，傅宏鑫。一种丁酸梭菌及其应用。中国发明专利：2019105107900。（已授权）
[3] 王菊芳, 王蒙, 马毅, 傅宏鑫。一种抗菌肽天蚕素A新型突变体及其编码基因、制备方法和应用。中国发明专利：201810868364X。（已授权）
[4]  王菊芳, 傅宏鑫，廖正平。一株耐受多种纤维素水解液抑制物的丙酮丁醇梭菌及其制备方法和应用。中国发明专利：201811173044。（已授权）
[5]  王菊芳，兰洋，冯骏，傅宏鑫，张凌蔚。一种丁酸梭菌及其在固定化发酵生产1，3-丙二醇的应用。中国发明专利：2020112390526。(已授权)
[6] 王菊芳，刘苏，马毅，傅宏鑫，王蒙。一种重组人源融合胶原蛋白及其高效羟基化方法与应用。中国发明专利：202210567560X。(已授权)
[7] 王菊芳, 郭晓龙, 傅宏鑫。一种生产丁酸丁酯的酪丁酸梭菌重组菌株及其构建方法和应用。中国发明专利: 2021115983621。
[8] 王菊芳，李艳梅，马毅，傅宏鑫，王蒙。一种人工合成抗菌肽及其应用。中国发明专利: 2022112211934。
[9] 王菊芳，刘子尧，傅宏鑫。一种能够合成GABA的酪丁酸梭菌基因工程菌及其构建方法与应用。中国发明专利: 2023102047209。

教学活动

微生物学、文献检索与实践、生物技术综合实验、基础生命科学

指导学生情况

生物学、发酵工程、生物工程、药学

我的团队

王菊芳教授团队