更新日期：2021年7月11日
工作经历
2016. 11 - 2019. 05：香港中文大学化学学院 博士后
2019. 05至今：华南理工大学生物科学与工程学院 副教授
教育经历
2008. 09-2012. 07：华中师范大学化学学院学士（化学与英语双学位）
2012. 08-2016. 11：香港中文大学化学学院博士
研究领域
（1）核酸分子（DNA和RNA）的结构、生物、物理及化学性质；
（2）高分辨率液体核磁共振（NMR）测定核酸及其他生物分子的三维空间结构；
（3）人类神经退行性疾病中基因不稳定性的机理；
（4）生物药物靶向作用的机制及药物设计；
（5）单分子技术研究生物大分子的生理学性质。
科研项目
国家自然科学基金青年基金项目，24万，在研，主持。
广东省自然科学基金面上项目，10万，在研，主持。
广州市基础与基础应用研究青年基金项目，5万，在研，主持。
华南理工大学双一流人才队伍建设项目，30万，在研，主持。
发表论文
按发表时间排序：
1. Peng S, Guo P, Lin X, An Y, Sze KH, Lau MHY, Chen ZS, Wang Q, Li W, Sun JK, Ma SY, Chan TF, Lau KF, Ngo JCK, Kwan KM, Wong CH, Lam SL, Zimmerman SC, Tuccinardi T, Zuo Z, Au-Yeung HY, Chow HM, Chan HYE*, CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118: e2022940118. (IF=11.2, Q1)
2. Wan L, Lam SL*, Lee HK, Guo P*, Effects of adenine methylation on the structure and thermodynamic stability of a DNA minidumbbell. International Journal of Molecular Sciences, 2021, 22: 3633. (IF=5.9, Q1)
3. Wan L, Yi J, Lam SL*, Lee HK, Guo P*, 5-Methylcytosine substantially enhances the thermal stability of DNA minidumbbell. Chemistry A European Journal, 2021, 27: 1. (IF: 5.2, Q1)
4. Wan L, Lam SL*, Lee HK, Guo P*, Rational design of a reversible Mg2+/EDTA-controlled molecular switch based on a DNA minidumbbell. Chemical Communications, 2020, 56: 10127. (IF: 6.2，Q1, 封面文章)
5. Guo P*, Lam SL*, Minidumbbell structures formed by ATTCT pentanucleotide repeats in spinocerebellar ataxia type 10. Nucleic Acids Research, 2020, 13: 7557. (IF: 17.0, Q1)
6. Ngai CK, Lam SL, Lee HK, Guo P*, High-resolution structures of DNA minidumbbells comprising type II tetraloops with a purine minor groove residue. Journal of Physical Chemistry B, 2020, 124: 5131. (IF: 3.0, Q3)
7. Guo P, Lam SL*, Unprecedented hydrophobic stabilizations from a reverse wobble T·T mispair in DNA minidumbbell. Journal of Biomolecular Structure & Dynamics, 2020, 38: 1946. (IF: 3.3, Q2)
8. Guo P, Chan HYE, Lam SL*, Conformational flexibility in the RNA stem-loop structures formed by CAG repeats. FEBS Letters, 2017, 591: 1752. (IF: 4.1, Q2)
9. Guo P, Lam SL*, An extraordinarily stable DNA minidumbbell. Journal of Physical Chemistry Letters, 2017, 8: 3478. (IF: 4.1, Q2)
10. Liu Y, Guo P, Lam SL*, Formation of a DNA mini-dumbbell with a quasi-type II loop. Journal of Physical Chemistry B, 2017, 121: 2554. (IF: 3.0, Q3)
11. Griffith JF*, Hu M, Yeung DKW, Guo P, Lam SL, Xiao F, Wang D, Tomlinson B, Achilles Tendon Xanthomas: Fat-Water Separation at Baseline and after Treatment. Radiology, 2017, 285: 876. (IF: 11.1, Q1)
12. Guo P, Lam SL*, Minidumbbell: A new form of native DNA structure. Journal of the American Chemical Society, 2016, 138: 12534. (IF: 15.4, Q1)
13. Guo P, Lam SL*, The competing mini-dumbbell mechanism: new insights into CCTG repeat expansion. Signal Transduction and Targeted Therapy, 2016, 1, 16028. (IF: 18.2, Q1)
14. Guo P, Lam SL*, Unusual structures of CCTG repeats and their participation in repeat expansion. Biomolecular Concepts, 2016, 7: 331-340.
15. Guo P, Lam SL*, New insights into the genetic instability in CCTG repeats. FEBS Letters, 2015, 589: 3058. (IF: 4.1, Q2)
16. Guo P, Lam SL*, Unusual structures of TTTA repeats in icaC gene of Staphylococcus aureus. FEBS Letters, 2015, 589: 1296. (IF: 4.1, Q2)
17. Yao S, Tam DY, Cheung PS, Lam CK, Guo P, Lam SL, Lee HK*, Cobalt(II) amido complexes derived from a monodentate arylamido ligand featuring a highly electron-withdrawing C6F5 substituent. Dalton Transactions, 2015, 44: 17950. (IF: 4.2, Q1)
18. Yao, S.; Tam, D. Y.; Cheung, P. S.; Lam, C. K.; Guo, P.; Lam, S. L.; Lee, H. K., Cobalt(II) amido complexes derived from a monodentate arylamido ligand featuring a highly electron-withdrawing C6F5 substituent. Dalton Transactions, 2015, 44 (41), 17950-17959.
19. Guo, P.; Wang, Q.; Liu, J.; Liu, L.; Zhao, P.; Cao, Y.; Liu, Y.; Qi, C.; Liu, Y., Preparation of two organoselenium compounds and their induction of apoptosis to SMMC-7221 cells. Biological Trace Element Research, 2013, 154 (2), 304-311.
20. Guo, P.; Zhao, P.; Liu, J.; Ma, H.; Bai, J.; Cao, Y.; Liu, Y.; He, H.; Qi, C., Preparation of a novel organoselenium compound and its anticancer effects on cervical cancer cell line HeLa. Biological Trace Element Research, 2013, 151 (2), 301-306.
21. Chen, D.; Guo, P.; Chen, S.; Cao, Y.; Ji, W.; Lei, X.; Liu, L.; Zhao, P.; Wang, R.; Qi, C.; Liu, Y.; He, H., Properties of xyloglucan hydrogel as the biomedical sustained-release carriers. Journal of Materials Science: Materials in Medicine, 2012, 23 (4), 955-962.
教学活动
讲授本科生全英课程《Bioinformatics》
讲授研究生课程《论文写作与学术规范》
指导学生情况
目前指导研究生5名